Article 22 1.

any change in his status, such as being a manufacturer, an importer or a producer of articles, or in his identity, such as his name or address;

any change in the composition of the substance as given in Section 2 of Annex VI;

changes in the annual or total quantities manufactured or imported by him or in the quantities of substances present in articles produced or imported by him if these result in a change of tonnage band, including cessation of manufacture or import;

new identified uses and new uses advised against as in Section 3.7 of Annex VI for which the substance is manufactured or imported;

new knowledge of the risks of the substance to human health and/or the environment of which he may reasonably be expected to have become aware which leads to changes in the safety data sheet or the chemical safety report;

any change in the classification and labelling of the substance;

any update or amendment of the chemical safety report or Section 5 of Annex VI;

the registrant identifies the need to perform a test listed in Annex IX or Annex X, in which cases a testing proposal shall be developed;

any change in the access granted to information in the registration.